Detalhe da pesquisa
1.
Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods.
PLoS Pathog
; 20(2): e1012007, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38386661
2.
Early administration of tecovirimat shortens the time to mpox clearance in a model of human infection.
PLoS Biol
; 21(12): e3002249, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38127878
3.
Oral Tecovirimat for the Treatment of Smallpox.
N Engl J Med
; 379(1): 44-53, 2018 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29972742
4.
Effects of Treatment Delay on Efficacy of Tecovirimat Following Lethal Aerosol Monkeypox Virus Challenge in Cynomolgus Macaques.
J Infect Dis
; 218(9): 1490-1499, 2018 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29982575
5.
Treatment with the smallpox antiviral tecovirimat (ST-246) alone or in combination with ACAM2000 vaccination is effective as a postsymptomatic therapy for monkeypox virus infection.
Antimicrob Agents Chemother
; 59(7): 4296-300, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25896687
6.
Effects of postchallenge administration of ST-246 on dissemination of IHD-J-Luc vaccinia virus in normal mice and in immune-deficient mice reconstituted with T cells.
J Virol
; 87(10): 5564-76, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23468500
7.
Efficacy of tecovirimat (ST-246) in nonhuman primates infected with variola virus (Smallpox).
Antimicrob Agents Chemother
; 57(12): 6246-53, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24100494
8.
A novel inhibitor of dengue virus replication that targets the capsid protein.
Antimicrob Agents Chemother
; 57(1): 15-25, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23070172
9.
Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase.
Antimicrob Agents Chemother
; 57(4): 1902-12, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23403421
10.
Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice.
Proc Natl Acad Sci U S A
; 107(2): 838-43, 2010 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-20080762
11.
Emerging pharmacological strategies for treating and preventing mpox.
Expert Rev Clin Pharmacol
; 16(9): 843-854, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37592723
12.
Overview of the regulatory approval of tecovirimat intravenous formulation for treatment of smallpox: potential impact on smallpox outbreak response capabilities, and future tecovirimat development potential.
Expert Rev Anti Infect Ther
; 21(3): 235-242, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36728515
13.
Tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations.
Nat Microbiol
; 7(12): 1951-1955, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36344621
14.
An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications.
Expert Rev Anti Infect Ther
; 19(3): 331-344, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32882158
15.
Co-administration of tecovirimat and ACAM2000™ in non-human primates: Effect of tecovirimat treatment on ACAM2000 immunogenicity and efficacy versus lethal monkeypox virus challenge.
Vaccine
; 38(3): 644-654, 2020 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31677948
16.
ST-246 inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation.
Antimicrob Agents Chemother
; 53(12): 4999-5009, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19752270
17.
Vaccination of BALB/c mice with Escherichia coli-expressed vaccinia virus proteins A27L, B5R, and D8L protects mice from lethal vaccinia virus challenge.
J Virol
; 82(7): 3517-29, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18199639
18.
Preliminary Screening and In Vitro Confirmation of Orthopoxvirus Antivirals.
Methods Mol Biol
; 2023: 143-155, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31240676
19.
A randomized phase II study of concurrent docetaxel plus vaccine versus vaccine alone in metastatic androgen-independent prostate cancer.
Clin Cancer Res
; 12(4): 1260-9, 2006 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16489082
20.
Phase I study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D)-TRICOM, with and without granulocyte-macrophage colony-stimulating factor, in patients with carcinoembryonic antigen-expressing carcinomas.
J Clin Oncol
; 23(4): 720-31, 2005 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15613691